10% off £35

Code:SAVE
Buy 1 Get 1 Half PriceSummer ShopOffersOffers HubBuy one get one 1/2 price25% off or moreOnline only 25% off or moreBuy 1 Get 1 FreePayday EventGreat SavingsOutletBetter than 1/2 price2 for £18 Mix & MatchLast chance to buy1/2 Price3 for £3 Mix & MatchVitamins & SupplementsVitamins & Supplements HubJoints, Aches & PainsImmunityGut HealthEnergyLow Mood & DepressionStress & AnxietyChildren's HealthHealthy HeartWeight ManagementSleep & RelaxationVitamins & Supplements Shop AllCBD Vitamins & SupplementsShop all CBD Vitamins & SupplementsCBD OilCBD CapsulesCBD SprayCBD GummiesCollagen & SilicaMuscle Support & Joint PainHair, Skin & NailsShop all Hair, Skin & NailsHair GrowthFunctional MushroomsVitaminsShop all VitaminsMultivitaminsVitamin AVitamin BVitamin CVitamin DVitamin EVitamin KVitamin DrinksMineralsShop all MineralsMagnesiumIronZincCalciumSeleniumChromiumSupplementsShop all SupplementsFibre SupplementsAcidophilus & Friendly BacteriaPeppermint OilGrapeseed ExtractLecithinCollagen & SilicaOmega & Fish OilsPlant Sourced SupplementsSuperfood SupplementsArnicaApple CiderRaspberry KetonesAloe VeraChondroitin & MSMCo Enzyme Q10Evening Primrose OilGarlicGinkgo BilobaGlucosamineGlucomannanSeaweed, Kelps and Aquaceuticals5 HTPDigestive EnzymesSaw palmettoCharcoalWomen's HealthShop all Women's HealthMenopauseMenstrual SupportUrinary Tract HealthPregnancy & ConceptionMen's HealthShop all Men's HealthProstate HealthChildren's HealthConditionShop all ConditionCholesterolAllergy & Hay Fever CareAnxiety SupportBone & Muscle HealthMuscle Support & Joint PainBrain & Memory SupportWomen's HealthMen's HealthChildren's HealthCold & Immune SupportFatigueDigestive HealthHair, Skin & NailsHeart & CirculationLiver CareMood SupportSexual HealthSleep & RelaxationStress ReliefVisionHerbal & Licensed RemediesShop all Herbal & Licensed RemediesRescue RemedyAshwagandhaMilk ThistleGinseng & GuaranaHomeopathic & Flower RemediesShop all Homeopathic & Flower RemediesRescue RemedyTissue SaltsFlower RemediesHomeopathic RemediesAt-Home TestsVegan Vitamins & SupplementsCBD Homeopathic Buy one get one 1/2 price25% off or moreOnline only 25% off or moreBuy 1 Get 1 FreePayday EventOutletLast chance to buyShort DatedHolland & BarrettVitabioticsSolgarNew NordicWeledaBioglanBetterYouGrass & Co.H&B ExpertNature's WayDairy FreeGluten FreeSesame Seed FreeCelery FreeCereal FreeCrustaceans FreeEgg FreeFish FreeKiwi FreeLupin FreeNew inFood & DrinkFood & Drink HubImmunityExercise & RecoveryGut HealthEnergyJoints, Aches & PainsWeight ManagementDental HealthFood & Drink Shop AllDried Fruit, Nuts & SeedsShop all Dried Fruit, Nuts & SeedsNutsDried FruitSeedsMixesHoney, Jams & SpreadsShop all Honey, Jams & SpreadsManuka HoneyHoneyNut ButtersJams & ChutneysSyrupsSpreadsPateDrinks & JuicesShop all Drinks & JuicesNatural Energy DrinksKombuchaJuices & Health ShotsSoft DrinksWaterProtein ShakesAlcohol Free DrinksTeas, Coffee & Hot BeveragesShop all Teas, Coffee & Hot BeveragesCoffee & Coffee SubstitutesMushroom DrinksTeasSuperfood TeasMatcha & Green TeaSleep & RelaxationPeppermint TeaSlimming TeaSuperfoodsShop all SuperfoodsSuperfood PowdersMoringa PowderMaca PowderChia SeedsFlaxseedSpirulinaGoji BerriesBaobabSnacksShop all SnacksProtein BarsLow Calorie SnacksChocolate, Cakes & BiscuitsCrisps & ChipsSavoury SnacksSweet SnacksSnack BarsFlapjacksPopcornVegan FoodShop all Vegan FoodMeat-Free AlternativesDairy AlternativesEgg SubstitutesVegan ProteinVegan Protein BarsFood CupboardShop all Food CupboardApple Cider VinegarCondiments & SaucesRice, Pasta, Pulses & GrainsTinned FoodsBreakfast CerealsBreakfast CerealsShop all Breakfast CerealsCereals, Bran & FlakesGranolaMuesliOats & PorridgeBreakfast BarsCookingShop all CookingCooking IngredientsApple Cider VinegarCondiments & SaucesMeat-Free AlternativesSoup & Ready MealsRice, Pasta, Pulses & GrainsHerbs, Spices & SeasoningGravy & StockHome BakingShop all Home BakingBaking MixesBreadFlourSweeteners & Sugar AlternativesEgg SubstitutesDairy AlternativesShop all Dairy AlternativesOat, Rice & Hemp DrinksSoya DrinksNut DrinksCoconut DrinksNutritionally Complete FoodBuy one get one 1/2 priceBuy 1 Get 1 Free25% off or morePayday EventOnline only 25% off or moreGreat SavingsBetter than 1/2 priceOutletHolland & BarrettNaturyaGrenadeHeath & HeatherHuelPukkaNakdTwiningsMeridianPhDGluten FreeDairy FreeWheat FreeEgg FreeSugar FreeMilk FreeSoya FreeSesame Seed FreeCelery FreeFish FreeNew inSports NutritionSports Nutrition HubExercise & RecoveryEnergyWeight ManagementLow Mood & DepressionStress & AnxietySports Nutrition Shop AllProteinShop all ProteinWhey ProteinClear ProteinMass GainersVegan ProteinDiet ProteinCaseinSports SupplementsShop all Sports SupplementsTestosteroneElectrolytesEnergy GelsSports CollagenPre Workout & EnergyShop all Pre Workout & EnergyPre WorkoutCaffeine-free-pre-workoutAmino Energy PowdersBars, Drinks & SnacksShop all Bars, Drinks & SnacksEnergy BarsProtein BarsProtein ShakesProtein SnacksNutritionally Complete FoodMeal Replacement ShakesIntra WorkoutKetoPost WorkoutAmino AcidsShop all Amino AcidsAmino Energy PowdersBCAACarnitineArginineCreatineShop all CreatineCreatine PowderCreatine CapsulesVegan Sports NutritionShop all Vegan Sports NutritionVegan ProteinVegan Protein BarsVegan Pre Workout & EnergyVegan Amino AcidsVegan CreatineSports AccessoriesShop all Sports AccessoriesBottles & ShakersFitness EquipmentFitness GoalShop all Fitness GoalRecoveryMuscle & StrengthLean MuscleEnergy & EnduranceDiet & Weight Loss25% off or moreGreat SavingsBuy one get one 1/2 priceLast chance to buyOnline only 25% off or more2 for £6.50 Mix & MatchFree PE Essential Amino AcidBuy 1 Get 1 FreeOptimum NutritionUSNGrenadePE NutritionApplied NutritionPhDHuelSiSFoodspringYfoodGluten FreeDairy FreeSugar FreeSoya FreePalm Oil FreeCelery FreeCereal FreeCrustaceans FreeEgg FreeFish FreeNew inBeautyBeauty HubSkin Health - by skin concernDental HealthWomen's Health - Cycles & MenstruationJoints, Aches & PainsWomen's Health - PregnancyChildren's HealthExercise & RecoveryImmunityLow Mood & DepressionSexual HealthNatural Beauty Shop AllAromatherapy & HomeShop all Aromatherapy & HomePure Essential OilsBlended Essential OilsBase & Carrier OilsHolisticSkincareShop all SkincarePremium SkincareFace CareBody CareSun CareTanning & BronzingEye CareLip CareFoot CareHand & Nail CareSkin AilmentsSkin OilsCBD BeautySun CareShop all Sun CareSun Lotion SPFMineral Sun CareFace SPFAfter SunHair Skin & NailsWashing & BathingShop all Washing & BathingShampoo & ConditionerBathing AccessoriesShower Gel & Body WashDeodorantDentalHand WashSoapBath Soak & OilBody ScrubBath Bombs & SaltsFeminine CareIncontinence SupportHair CareShop all Hair CareShampoo & ConditionerHair ColouringHair MasksHair Oil & SerumHair Spray, Gel & MousseHair AccessoriesMother & BabyShop all Mother & BabyBaby Skincare & ToiletriesElectrical WellnessSexual WellnessBuy one get one 1/2 price25% off or moreOnline only 25% off or moreOutletBuy 1 Get 1 Free2 for £18 Mix & MatchPayday EventGreat SavingsDr OrganicFaith in NatureWeledaNaturtintTisserandMiaromaSukinQ+AEthiqueTrilogyAlcohol FreePalm Oil FreeParfum FreeGluten FreeMicroplastics FreeCelery FreeCereal FreeCrustaceans FreeDairy FreeEgg FreeNew inCBDShop all CBDExercise & RecoveryLow Mood & DepressionStress & AnxietySleep & RelaxationCBD Vitamins & SupplementsShop all CBD Vitamins & SupplementsCBD OilCBD CapsulesCBD SprayCBD GummiesCBD Food DrinkCBD BeautyBuy 1 Get 1 FreeBuy one get one 1/2 pricePayday Event25% off or moreOnline only 25% off or more1/2 PriceGreat SavingsOutletLove HempGrass & Co.CBDfxTRIPfourfiveHolistic HerbCannaray CBDReakiroHolland & BarrettBody & Mind BotanicalsDairy FreeAlcohol FreeGluten FreeNew inWeight ManagementWeight Management HubExercise & RecoveryWeight ManagementEnergyHealthy HeartWeight Management Shop AllFat Burners, Binders & Appetite SuppressantsShop all Fat Burners, Binders & Appetite SuppressantsFat BurnersFat BindersAppetite SuppressantsSlimming TabletsWeight Management Shakes Shop all Weight Management Shakes Meal Replacement ShakesDiet ProteinDiet Food & DrinkShop all Diet Food & DrinkDiet FoodLow Calorie SnacksSlimming TeaExercise SupportShop all Exercise SupportFitness EquipmentMeal Replacement ShakesDiet ProteinProtein BarsBuy one get one 1/2 price25% off or moreGreat SavingsBuy 1 Get 1 FreeOnline only 25% off or morePayday EventGrenadeOptimum NutritionHolland & BarrettUSNEat WaterNew NordicPhDPulsinSlimExpertApplied NutritionGluten FreeSugar FreeDairy FreeWheat FreeNew inVeganHealth & WellnessShop all Health & WellnessJoints, Aches & PainsGut HealthSkin Health - by skin concernEnergyWomen's Health - Menopause & PerimenopauseLow Mood & DepressionStress & AnxietyWomen's Health - Hormonal HealthImmunityExercise & RecoveryJoints Bones & MusclesGut HealthHair Skin & NailsStress AnxietySleep & RelaxationBuy one get one 1/2 price25% off or moreOnline only 25% off or moreBuy 1 Get 1 FreePayday Event2 for £18 Mix & MatchGreat SavingsOutletHolland & BarrettVitabioticsWeledaSolgarDr OrganicNaturtintOptimum NutritionBetterYouNew NordicBioglanDairy FreeGluten FreeAlcohol FreeSugar FreeWheat FreeSoya FreeSesame Seed FreeCelery FreeCereal FreeCrustaceans FreeNew inShop for your WellnessJoints, Bones & MusclesWomen's HealthMenstrual HealthMenopauseSkincareGut HealthHair, Skin & NailsImmunitySleep & RelaxationFood & DietChildren's HealthStress ReliefHealthy HeartEnergyLow Mood & DepressionConcentration & AlertnessEye HealthSexual HealthLearn about WellnessJoints, Bones & MusclesWomen's HealthPeriods & Cycle HealthMenopauseImmunityGut HealthFood & DietSports & FitnessSleep & RelaxationHair Skin & NailsArticlesAll articlesHealthFood & nutritionGut healthImmunityJoints, bones & musclesWomen's healthWellnessHair & skinMental wellbeingSeasonalSleep & relaxationSports nutritionRecipesAll recipesGluten freeLow sugarVeganDairy freePodcast

Explore related topics

Ashwagandha guide: Benefits, dosage, supplements & more

Laura Harcourt

Written byLaura Harcourt

Ashwagandha capsules in females hand
Ashwagandha is an ancient medicinal herb with many uses, such as pain relief, boosting your immune system and inflammation.

Summary

1What is ashwagandha?

Ashwagandha is a small evergreen shrub that originates from parts of India, the Middle East, and Africa...

2The health benefits of ashwagandha

Potential uses of ashwagandha that have been researched include effects on stress, sexual function, fertility and more...

3What does ashwagandha do?

Ashwagandha is an adaptogen, a natural agent that reportedly helps the body cope with stress according to this particular study...

Ashwagandha has been used for centuries in traditional medicine in India, with praises for its medicinal properties – but what makes it special and is there any science to it?1

Ashwagandha, commonly used in Indian ayurvedic medicine, has traditionally been used to help almost everything, from arthritis to rheumatism. Some use it as a general tonic to increase energy, and improve overall health, while others use it to prevent illness in athletes and the elderly.1

It's worth noting though, that ashwagandha is not recommended for use during pregnancy and lactation, plus if you’re taking medication, you always should consult with a healthcare professional before starting use.

So, what's the evidence to back up these so-called benefits that have been linked to using ashwagandha, or its KSM-66 extract? In this article, you’ll discover everything there is to know.

What is ashwagandha? 

Ashwagandha is a small evergreen shrub that originates from parts of India, the Middle East, and Africa.1 Its unusual name relates to the way it smells – ashwagandha roots smell like a horse, with ‘ashva’ meaning ‘horse’ and ‘gandha’ meaning ‘smelling like’ in Sanskrit.2 

The entire plant is harvested, dried, and ground down into a powder, which is sold as ashwagandha supplements.2 The ashwagandha plant has been traditionally renowned by those who believe in Ayurvedic medicine as one of the most powerful herbs, which spans back thousands of years.1 

Typically, when people refer to ashwagandha, they're referring to the extract.

What's the difference between KSM-66 and ashwagandha? 

The difference between KSM-66 and regular ashwagandha is that traditional ashwagandha is composed of extracts derived from both the leaf and root of the ashwagandha plant, whereas KSM-66 follows a conventional approach and is composed solely of root extract.3

The health benefits of ashwagandha 

Ashwagandha has been used for many things over the last 3,000 years. 

Potential uses of ashwagandha that have been researched include effects on stress, sexual function and fertility, athletic performance, cognitive performance, pain, fatigue, thyroid function, diabetes, hypercholesterolemia, and tuberculosis. Initial findings for some of these conditions have been promising, but more robust clinical study designs are needed before confirming its benefits. 

Our video recap explains all the potential health benefits of ashwagandha, its history, and how to use it.

Benefits of Ashwagandha | Debunking Wellness | H&B

Although ashwagandha has a long list of potential benefits, is there any scientific evidence behind it? 

There have been many scientific studies on ashwagandha, many of which, however, have small sample sizes, short duration times, and other limitations. So, further robust studies are needed to confirm these potential benefits.
Nonetheless, some promising findings from the following studies suggest ashwagandha and KSM-66 may help with the following:

May reduce stress

Two studies investigated how ashwagandha might help reduce mild stress, but more research is needed with diverse and larger populations and varying dosages.4,5
 

May help with fatigue

A scientific study involving 120 participants researched fatigue levels and found that ashwagandha may have ‘anti-fatigue’ effects through its effect on the autonomic nervous system’6
 

May increase testosterone

One study looked into the link between ashwagandha and stress in 60 people, but as an adverse effect actually found that testosterone levels increased in the male participants during the study.5 They didn’t observe the same effects in the female participants.5
 

May help with poor memory

Another placebo-controlled study involving 60 participants found that one ashwagandha capsule per day for 90 days improved memory in participants who were stressed.7
 

May improve concentration

Focus can be heavily affected by stress, so based on the findings discussed earlier, we are not surprised that in the same scientific study where they found memory improvement, they found that ashwagandha improved concentration in people who reported high levels of stress.8
 

May help with better quality sleep

A 2021 study found that one ashwagandha capsule per day helped improve sleep quality in participants.8
 

May help with low libido

Two independent studies both found that ashwagandha helped people involved in their studies have better quality ‘sexual function’.8,9
 

May improve endurance

Anecdotally, ashwagandha is supposed to help with endurance of any kind. Studies into this are rare, but one 2015 study did find that ashwagandha helped improve lung endurance in 50 healthy athletic adults.10
 

May reduce joint pain

A 2021 study suggested that it might be useful to help manage joint pain in people with arthritis, but again this was a small study and authors acknowledged that studies with more than 100 participants are needed.11
 

May help with neurological conditions

A 2020 study evaluating the link between ashwagandha and brain disorders, concluded it might be a promising drug target. 13 However, they also concluded that because a lot of these neurological conditions are not very well understood, it is hard to know whether ashwagandha affects these conditions directly.12
 

Disclaimer

Please note scientific evidence for this product is very limited and although there are emerging studies, more clinical research needs to be conducted. Please speak to your GP before taking any new products.
 

What does ashwagandha do?

Ashwagandha is an adaptogen, a natural agent that reportedly helps the body cope with stress according to this particular study.13 There is a lot of research on the potential effects of ashwagandha, but we still don’t know how it works on the body or if these effects would be seen in larger studies. 

One thing that is known is that ashwagandha also contains a large amount of Withanolides, which are one of the primary active ingredients in ashwagandha. The level of Withanolides, which are mainly found in ashwagandha roots, varies from one extract to the other.14

As with taking any supplement, it’s important that ashwagandha is taken in line with the manufacturer’s guidance. Ashwagandha is believed to be safe for most people to take, although its long-term effects are unknown.15 

Typical doses, taken on a short-term basis, may cause mild to moderate side effects, such as headaches, sleepiness and stomach upsets.15 You should avoid taking it if you're pregnant, breastfeeding, taking certain medications, or have an autoimmune disease or if advised by your GP.

The final say 

We hope you’re feeling more clued up about ashwagandha, especially when it comes to knowing what it’s used for and potentially, how to start using it yourself. 

Ashwagandha has been researched for a range of possible benefits, including reducing stress and fatigue, increasing testosterone in men, improving sexual well-being in all genders, reducing joint pain and helping with better quality sleep. More robust studies are needed to confirm the benefits of ashwagandha, we don't know if these effects would be replicated in larger studies, but for now, some preliminary research shows promising results and encourages further study.5,6,7,8,9,12

Disclaimer

This product is not suitable if you are pregnant, breastfeeding, taking any medications, or have endocrine disorders, liver or heart problems, or clinical depression. This product is not intended for use by persons under the age of 18.
 

Sources

1. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Alternative medicine review. 2000. Available at: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=2bdff82eb23a373885252c87b53135b2fc9adde4
2. Rajeswara Rao BR, Rajput DK, Nagaraju G, Adinarayana G. Opportunities and challenges in the cultivation of Ashwagandha {Withania somnifera (L.) Du-nal}. Journal of Pharmacognosy, ISSN. 2012. Available at: https://www.researchgate.net/profile/Adi-G/publication/264289020_OPPORTUNITIES_AND_CHALLENGES_IN_THE_CULTIVATION_OF_ASHWAGANDHA_Withania_somnifera_L_DUNAL/links/53d79f780cf2631430bfbadf/OPPORTUNITIES-AND-CHALLENGES-IN-THE-CULTIVATION-OF-ASHWAGANDHA-Withania-somnifera-L-DUNAL.pdf
3. Tripathi N, Shrivastava D, Mir BA, Kumar S, Govil S, Vahedi M, Bisen PS. Metabolomic and biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A review. Phytomedicine. 2018. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0944711317301101
4. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750292/
5. Akhgarjand C, Asoudeh F, Bagheri A, Kalantar Z, Vahabi Z, Shab‐bidar S, Rezvani H, Djafarian K. Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2022. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.7598
6. Smith SJ, Lopresti AL, Fairchild TJ. Exploring the efficacy and safety of a novel standardized ashwagandha (Withania somnifera) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. Journal of Psychopharmacology. 2023. Available at: https://journals.sagepub.com/doi/full/10.1177/02698811231200023
7. Gopukumar K, Thanawala S, Somepalli V, Rao TS, Thamatam VB, Chauhan S. Efficacy and safety of ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Evidence-Based Complementary and Alternative Medicine. 2021. Available at: https://www.hindawi.com/journals/ecam/2021/8254344/
8. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of Ashwagandha (Withania somnifera) root extract in improving sexual function in women: a pilot study. BioMed research international. 2015. Available at: https://www.hindawi.com/journals/bmri/2015/284154/
9. Chauhan S, Srivastava MK, Pathak AK. Effect of standardized root extract of ashwagandha (Withania somnifera) on well‐being and sexual performance in adult males: A randomized controlled trial. Health Science Reports. 2022. Available at: https://onlinelibrary.wiley.com/doi/full/10.1002/hsr2.741
10. Choudhary B, Shetty A, Langade DG. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults. Ayu. 2015. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687242/
11. Kanjilal S, Gupta AK, Patnaik RS, Dey A. Analysis of clinical trial registry of India for evidence of anti-arthritic properties of Withania somnifera (ashwagandha). Altern. Ther. Health Med. 2021. Available at: http://www.alternative-therapies.com/oa/pdf/65961.pdf
12. Zahiruddin S, Basist P, Parveen A, Parveen R, Khan W, Ahmad S. Ashwagandha in brain disorders: A review of recent developments. Journal of ethnopharmacology. 2020. Available at: https://www.sciencedirect.com/science/article/abs/pii/S0378874119339182
13. Bonilla DA, Moreno Y, Gho C, Petro JL, Adrián Odriozola-Martínez, Kreider RB. Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis. Journal of Functional Morphology and Kinesiology [Internet]. 2021 Feb 11 [cited 2024 Feb 1];6(1):20–0. Available from: https://pubmed.ncbi.nlm.nih.gov/33670194/
14. Samadi A. Potential Anticancer Properties and Mechanisms of Action of Withanolides. The Enzymes [Internet]. 2015 Jan 1 [cited 2023 Dec 19];73–94. Available from: https://www.sciencedirect.com/topics/neuroscience/withanolide
15. Verma N, Gupta SK, Tiwari S, Mishra AK. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. Complementary therapies in medicine. 2021. Available at: https://www.sciencedirect.com/science/article/pii/S0965229920319099
 

Explore related topics

Related Articles

  • Visa
  • MasterCard
  • PayPal
  • AmericanExpress
  • ApplePay
  • ClearPay
  • AliPay
  • Instagram
  • Pinterest
  • Facebook
  • Twitter
Copyright © Holland & Barrett Retail Limited, 2024. All rights reserved. hollandandbarrett.com is a trading name of Holland & Barrett Retail Limited,. Registered office: Samuel Ryder House, Barling Way, Nuneaton, Warwickshire CV10 7RH. Registered in England: company no. 2758955. Registered VAT no. 211727395.