Explore related topics

Our best NAD+ supplements: liposomal NAD+, NR and more

Selection of energy product on green background
Thinking of trying NAD+ but wondering what the differences are? We take a closer look at our NAD+, NR and longevity supplements and explain what makes each option different

Our top picks

One per day

Holland & Barrett Liposomal NAD+ 300mg​ 30 Capsules
4.83

Holland & Barrett

Holland & Barrett Liposomal NAD+ 300mg​ 30 Capsules

3 for 2 Mix & Match

£29.99

300mg NR

Paused NR Nicotinamide Riboside Complex 300mg 30 Capsules
5

Paused

Paused NR Nicotinamide Riboside Complex 300mg 30 Capsules

£24.49

RRP £34.99

Energy support

Holland & Barrett Super Strength Co-Q10 200mg 30 Capsules
4.66

Holland & Barrett

Holland & Barrett Super Strength Co-Q10 200mg 30 Capsules

Buy 1 Get 1 Free

£35.29

Explore related topics

From liposomal NAD+ to NR, there’s plenty of scientific-sounding names to unpick. But what do NAD+ supplements actually mean, and how can the products differ? H&B Senior Scientist Dr Laure Verstraeten helps us make sense of the different options.

What are NAD+ supplements?

If you’ve been exploring NAD+ supplements as part of daily wellbeing, you may have come across terms like NAD+, liposomal NAD+ and NR. While they’re closely related, they aren’t all the same type of supplement:

  • NAD+ supplements provide nicotinamide adenine dinucleotide (NAD+) itself. Different products may provide different amounts of NAD+ or combine it with additional vitamins and minerals. The relationship between NAD+ levels and ageing is an area of growing scientific interest, although research in humans is still emerging

  • liposomal NAD+ also provides NAD+, but it uses what’s called a liposomal formulation. Liposomes are tiny structures made from lipids (fats) that are used as a delivery format for certain ingredients. Depending on the supplement, this may make it easier for the body to absorb 1

  • NAD+ precursors do not contain NAD+. Instead, they provide compounds the body can use to make NAD+.2 One example is nicotinamide riboside (NR), a form of vitamin B3. As well as being taken in supplement form, NR is naturally found in milk 2

Our top NAD+ supplements

If NAD+ has piqued your interest, take a look at our supplement picks below. We’ll explain what makes each one special...

Holland & Barrett Liposomal NAD+ 300mg​ 30 Capsules

One per day

Holland & Barrett

£29.99

£1.00/1 Capsule

Higher-strength, liposomal NAD+

Our higher-strength capsules provide 300mg NAD+, ideal for those looking for more than our standard 100mg. But that’s not all: what sets this product apart from the other NAD+ supplements in the H&B range is its liposomal formulation. Each capsule also contains vitamin C to support immune function, plus niacin, which contributes to normal energy-yielding metabolism (turning food into energy) and plays a role in reducing tiredness and fatigue.3,4,5

 
Paused NAD+ Complete 500 mg 60 Capsules

Energy support

Paused

RRP £49.99

£34.99

£0.58/1 Capsule

Multivit blend, with added NAD+

Want to add NAD+ to your daily multivitamin? Paused’s NAD+ Complete formula helps keep your supplement routine simple, with 500mg NAD+ and a blend of vitamins which support energy. Rather than focusing on NAD+ alone, it combines it with magnesium and vitamins B2, B3 and B6 which support normal energy-yielding metabolism, the reduction of tiredness and fatigue, and folic acid, zinc and selenium which contribute to normal immune system function and more.4-15 Aside from magnesium, you’ll get 100% of your daily nutrient reference value (NRV) of these micronutrients – making it a comprehensive multi-nutrient NAD+ formula.

 
Holland & Barrett NAD+ 60 Capsules

100mg NAD+

Holland & Barrett

£19.99

£0.33/1 Capsule

NAD+, niacin, no fuss

If you prefer to keep things simple, our standard capsules might just be for you. Each one provides 100mg NAD+, alongside 100% of your daily niacin (vitamin B3) to support energy-yielding metabolism and the reduction of tiredness and fatigue.4,5 Just take one capsule per day with a meal.

 
Paused NR Nicotinamide Riboside Complex 300mg 30 Capsules

300mg NR

Paused

RRP £34.99

£24.49

£0.82/1 Capsule

Supports NAD+ production

This product’s different from the other three because its main ingredient is nicotinamide riboside (NR) - an NAD+ precursor rather than NAD+ itself. NR is a form of vitamin B3 and a precursor that the body can use to make NAD+.2

Each capsule provides 300mg NR, alongside Siberian ginseng. The formula also contains, vitamin C and a blend of B vitamins including vitamins B2, B6 and B12, which contribute to normal energy-yielding metabolism, plus folic acid, which also contributes to the reduction of tiredness and fatigue.9,12,13,16-19 If you’re comparing the range, the key distinction is simple: the other three products supply NAD+ directly, while this one supplies NR as part of a wider vitamin and botanical complex.

 

Other healthy ageing products at H&B

Why not browse our other picks? The products below don’t contain NAD+ or NR, but they’re designed to support areas of healthy ageing like cognitive function and more.

SOOO cellular: Quercetin, Fisetin, L-Glycine 60 Capsules

Cognitive support

Sooo.me

£59.90

£1.00/1 Capsule

Supplements, made SOOO simple

SOOO’s vibrant capsules bring together plant compounds, an amino acid and a mineral rather than focusing on one main ingredient. Each daily serving provides 500mg quercetin from Japanese pagoda tree flower extract and 200mg fisetin from European smoketree extract. They’re paired with 100mg L-glycine (an amino acid involved in protein synthesis and collagen production).

To finish off the mix, there’s 50% of your daily recommended zinc – an important mineral which contributes to the protection of cells, normal cognitive and immune function and plays a role in cell division.20-23 Take two capsules per day, ideally in the morning.

 
Holland & Barrett Resveratrol 225mg with Red Wine Extract 10mg 60 Capsules

With polyphenols

Holland & Barrett

£24.99

£0.42/1 Capsule

Resveratrol and red wine extract (yes, really)

Ever thought you’d add red wine to your supplement routine? Our H&B formula provides a concentrated resveratrol extract sourced from Japanese knotweed root alongside 10mg red wine extract.

Resveratrol is a naturally occurring plant compound belonging to the polyphenol family. It's found naturally in several plants and foods, including the skins of red grapes, which is why it's also associated with red wine. Here, resveratrol is supplied in a concentrated form alongside a smaller amount of red wine extract. Unlike the SOOO product, this is a more focused plant-compound formula rather than a combination of several different types of nutrients.

 
Holland & Barrett Super Strength Co-Q10 200mg 30 Capsules

Energy support

Holland & Barrett

£35.29

£1.18/1 Capsule

Higher-strength co-Q10

Need a refresher on co-Q10? It’s a naturally occurring compound found in almost every cell in the body where it plays a role in energy production. The highest concentrations of co-Q10 are found in energy-demanding organs like the heart, liver and kidneys.24 However, our bodies’ natural stores of co-Q10 can decline as we age.24

Our higher-strength capsules contain 200mg co-Q10 per serving (one capsule), as well as vitamin B1 (thiamin), which contributes to normal energy-yielding metabolism and normal function of the heart.25 co-Q10 comes in two forms: ubiquinone and ubiquinol. Your body can convert between them, and this supplement contains ubiquinone. It's a useful difference to know when comparing co-Q10 products.

 

NAD+ and healthy ageing FAQs

What's the difference between NAD+ and NR supplements?

NAD+ helps enzymes in your body to do their jobs efficiently.26 One of its most important roles is helping to convert nutrients from food into energy. On the other hand, NR doesn’t contain NAD+. It’s a precursor to NAD+, which means it provides ingredients the body can use to make it.2

 

What is liposomal NAD+?

Liposomal NAD+ provides NAD+, but in a liposomal formulation. Liposomes are tiny structures made from fats that are used as a way to deliver certain ingredients into the body. Depending on the supplement, this may make it easier for the body to absorb.1

 

How do I choose between NAD+ supplements?

When you’re choosing NAD+ supplements, you might want to consider:

  • whether you take NAD+ or NR

  • strength

  • any added ingredients

  • how many you’d prefer to take per day

  • standard vs liposomal formats

  • your budget

You should also speak to your GP before trying any supplements to make sure they’re right for you.

 

The final say

And there you have it: a closer look at some of our standout NAD+ supplements and what makes each one special. Supplements aren’t one-size-fits-all, so you should always talk to your GP before starting something new. In the meantime, why not get savvy on the science behind NAD+ and energy, or discover our guide to longevity and living well?

Disclaimer – This article provides informational advice and is not a substitute for medical care. Working with experts for accuracy, we take great care to ensure the information is up-to-date and relevant. However, you should always consult your GP or healthcare professional before using supplements or alternative products, particularly if you have medical conditions or are under supervision.

Sources

1 National Cancer Institute (NIH). NCI Dictionary [Internet]. NIH [cited 2026 Oct 23]. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/liposomal

2 Mehmel M, Jovanović N, Spitz U. Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients [Internet]. 2020 May 31 [cited 2026 Oct 23]; 12(6): 1616. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7352172/

3 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6510

4 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6424

5 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6428

6 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6401

7 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6403

8 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6463

9 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6450

10 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6458

11 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6497

12 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6498

13 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6491

14 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6375

15 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6376

16 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6458

17 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6482

18 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6488

19 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6376

20 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6546

21 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6533

22 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6545

23 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6547

24 De Barcelos IP, Haas RH. CoQ10 and Aging. Biology (Basel) [Internet]. 2019 May 11 [cited 2026 Oct 23]; 8(2): 28. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6627360/

25 European Commission. Food and Feed Information [Internet]. European Commission [cited 2026 Oct 23]. Available from: https://ec.europa.eu/food/food-feed-portal/screen/health-claims/eu-register/details/POL-HC-6472

26 Conlon NJ. The Role of NAD+ in Reconstructive Medicine. Plast Reconstr Surg [Internet]. 2021 Sep 28 [cited 2026 Oct 23]; 150(4 Suppl): 41S-48S. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/

 
Related to this article
Sign up for exclusive offers

Plus, get expert advice to support your health & wellness straight to your inbox when you sign up to Holland & Barrett emails.